Seradex-LA

Generic Name: brompheniramine and phenylephrine (BROM fen IR a meen and FEN il EFF rin)

Brand Names: Alacol, Alenaze-D, Alenaze-D NR, B-Vex D, BPM PE, Brom Tann PE, Bromfed, Bromfed-PD Capsules, BroveX ADT, BroveX PEB, Brovex-D, Children's Cold & Allergy, Dimaphen Elixir, Dimetapp Cold & Allergy, Entre-B, J-Tan D, J-Tan D SR, Phenyl 15/12mg, Phenyl 7.5/6mg, RespaHist II, Rhinabid, Rhinabid PD, Seradex-LA, Tanabid SR, V-Hist, VazoBid, VaZol-D, Vazotab, Zotex-PE

What is Seradex-LA (brompheniramine and phenylephrine)?

Brompheniramine is an antihistamine that reduces the natural chemical histamine in the body. Histamine can produce symptoms of sneezing, itching, watery eyes, and runny nose.

Phenylephrine is a decongestant that shrinks blood vessels in the nasal passages. Dilated blood vessels can cause nasal congestion (stuffy nose).

The combination of brompheniramine and phenylephrine is used to treat nasal congestion, sneezing, itching, watery eyes, and runny nose caused by allergies, hay fever, and the common cold.

Brompheniramine and phenylephrine may also be used for purposes not listed in this medication guide.

What is the most important information I should know about Seradex-LA (brompheniramine and phenylephrine)?

Do not give this medication to a child younger than 4 years old. Always ask a doctor before giving a cough or cold medicine to a child. Death can occur from the misuse of cough and cold medicines in very young children. You should not use this medication if you are allergic to brompheniramine or phenylephrine, or to other decongestants, diet pills, stimulants, or ADHD medications. Do not use brompheniramine and phenylephrine if you have used an MAO inhibitor such as furazolidone (Furoxone), isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam, Zelapar), or tranylcypromine (Parnate) in the last 14 days. A dangerous drug interaction could occur, leading to serious side effects.

Ask a doctor or pharmacist about taking brompheniramine and phenylephrine if you have heart disease or high blood pressure, diabetes, a thyroid disorder, glaucoma, kidney disease, an enlarged prostate, or problems with urination.

What should I discuss with my healthcare provider before taking Seradex-LA (brompheniramine and phenylephrine)?

You should not use this medication if you are allergic to brompheniramine or phenylephrine, or to other decongestants, diet pills, stimulants, or ADHD medications. Do not use brompheniramine and phenylephrine if you have used an MAO inhibitor such as furazolidone (Furoxone), isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam, Zelapar), or tranylcypromine (Parnate) in the last 14 days. A dangerous drug interaction could occur, leading to serious side effects.

Ask a doctor or pharmacist if it is safe for you to take brompheniramine and phenylephrine if you have:

• 
  

  heart disease or high blood pressure;

  
  


• 
  

  diabetes;

  
  


• 
  

  a thyroid disorder;

  
  


• 
  

  glaucoma;

  
  


• 
  

  kidney disease;

  
  


• 
  

  an enlarged prostate; or

  
  


• 
  

  problems with urination.

  
  

FDA pregnancy category C. It is not known whether brompheniramine and phenylephrine will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using this medication. Brompheniramine and phenylephrine can pass into breast milk and may harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

How should I take Seradex-LA (brompheniramine and phenylephrine)?

Use exactly as directed on the label, or as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended. Cough or cold medicine is usually taken only for a short time until your symptoms clear up.

Do not give this medication to a child younger than 4 years old. Always ask a doctor before giving a cough or cold medicine to a child. Death can occur from the misuse of cough and cold medicines in very young children. Take the medicine with a full glass of water. Do not crush, chew, break, or open an extended-release capsule. Swallow it whole. Breaking or opening the pill may cause too much of the drug to be released at one time.

The chewable tablet must be chewed before you swallow it.

Measure liquid medicine with a special dose-measuring spoon or cup, not a regular table spoon. If you do not have a dose-measuring device, ask your pharmacist for one.

Shake the oral suspension (liquid) well just before you measure a dose. Do not take brompheniramine and phenylephrine for longer than 7 days in a row. Talk with your doctor if your symptoms do not improve after 7 days of treatment, or if you have a fever with a headache, cough, or skin rash. Store at room temperature away from moisture and heat.

What happens if I miss a dose?

Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose symptoms may include feeling restless or nervous, nausea, vomiting, stomach pain, dizziness, drowsiness, dry mouth, warmth or tingly feeling, or seizure (convulsions).

What should I avoid while taking Seradex-LA (brompheniramine and phenylephrine)?

This medication may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert.

Avoid becoming overheated or dehydrated during exercise and in hot weather.

Drinking alcohol can increase certain side effects of brompheniramine and phenylephrine. Ask a doctor or pharmacist before using any other cold, cough, allergy, or pain medicine. Antihistamines and decongestants are contained in many combination medicines. Taking certain products together can cause you to get too much of a certain drug. Check the label to see if a medicine contains an antihistamine or decongestant.

Avoid taking this medication if you also take diet pills, caffeine pills, or other stimulants (such as ADHD medications). Taking a stimulant together with a decongestant can increase your risk of unpleasant side effects.

Seradex-LA (brompheniramine and phenylephrine) side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Stop using this medication and call your doctor at once if you have a serious side effect such as:

• 
  

  fast, pounding, or uneven heartbeat;

  
  


• 
  

  severe dizziness, anxiety, restless feeling, or nervousness;

  
  


• 
  

  easy bruising or bleeding, unusual weakness, fever, chills, body aches, flu symptoms;

  
  


• 
  

  nausea, upper stomach pain, itching, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes); or

  
  


• 
  

  dangerously high blood pressure (severe headache, blurred vision, buzzing in your ears, anxiety, confusion, chest pain, shortness of breath, uneven heartbeats, seizure).

  
  

Less serious side effects may include:

• 
  

  drowsiness or dizziness;

  
  


• 
  

  blurred vision;

  
  


• 
  

  dry mouth, nose, or throat;

  
  


• 
  

  mild stomach pain, constipation;

  
  


• 
  

  problems with memory or concentration;

  
  


• 
  

  feeling restless or excited (especially in children);

  
  


• 
  

  sleep problems (insomnia); or

  
  


• 
  

  warmth, redness, or tingly feeling under your skin.

  
  

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Seradex-LA (brompheniramine and phenylephrine)?

Before using brompheniramine and phenylephrine, tell your doctor if you regularly use other medicines that make you sleepy (such as cold or allergy medicine, sedatives, narcotic pain medicine, sleeping pills, muscle relaxers, and medicine for seizures, depression, or anxiety). They can add to sleepiness caused by brompheniramine and phenylephrine.

Tell your doctor about all other medications you are using, especially:

• 
  

  medicines to treat high blood pressure;

  
  


• 
  

  a beta blocker such as atenolol (Tenormin, Tenoretic), carvedilol (Coreg), labetalol (Normodyne, Trandate), metoprolol (Dutoprol, Lopressor, Toprol), nadolol (Corgard), propranolol (Inderal, InnoPran), sotalol (Betapace), and others; or

  
  


• 
  

  antidepressants such as amitriptyline (Elavil), clomipramine (Anafranil), imipramine (Janimine, Tofranil), and others.

  
  

This list is not complete and other drugs may interact with brompheniramine and phenylephrine. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.

More Seradex-LA resources

• Seradex-LA Side Effects (in more detail)
• Seradex-LA Use in Pregnancy & Breastfeeding
• Seradex-LA Drug Interactions
• Seradex-LA Support Group
• 0 Reviews for Seradex-LA - Add your own review/rating

• Alenaze-D Elixir MedFacts Consumer Leaflet (Wolters Kluwer)


• Bromfed MedFacts Consumer Leaflet (Wolters Kluwer)


• BroveX-D Suspension MedFacts Consumer Leaflet (Wolters Kluwer)


• Entre-B Prescribing Information (FDA)


• J-Tan D Chewable Tablets MedFacts Consumer Leaflet (Wolters Kluwer)


• Rhinabid Sustained-Release Capsules MedFacts Consumer Leaflet (Wolters Kluwer)

Compare Seradex-LA with other medications

• Hay Fever
• Nasal Congestion
• Rhinitis

Where can I get more information?

• Your pharmacist can provide more information about brompheniramine and phenylephrine.

See also: Seradex-LA side effects (in more detail)

Novo-Cholamine

Generic Name: cholestyramine (Oral route)

koe-le-STYE-ra-meen

Commonly used brand name(s)

In the U.S.

• Prevalite


• Questran


• Questran Light

In Canada

• Novo-Cholamine


• Novo-Cholamine Light

Available Dosage Forms:

• Powder for Suspension


• Tablet

Therapeutic Class: Antihyperlipidemic

Pharmacologic Class: Bile Acid Sequestrant

Uses For Novo-Cholamine

Cholestyramine is used to lower high cholesterol levels in the blood. This may help prevent medical problems caused by cholesterol clogging the blood vessels. Cholestyramine is also used to remove substances called bile acids from your body. With some liver problems, there is too much bile acid in your body and this can cause severe itching.

Cholestyramine works by attaching to certain substances in the intestine. Since cholestyramine is not absorbed into the body, these substances also pass out of the body without being absorbed.

Cholestyramine may also be used for other conditions as determined by your doctor.

Cholestyramine is available only with your doctor's prescription.

Once a medicine has been approved for marketing for a certain use, experience may show that it is also useful for other medical problems. Although these uses are not included in product labeling, cholestyramine is used in certain patients with the following medical conditions:

• Digitalis glycoside overdose


• Excess oxalate in the urine

Before Using Novo-Cholamine

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

This medicine has been tested in a limited number of children. In effective doses, the medicine has not been shown to cause different side effects or problems than it does in adults.

Geriatric

Side effects may be more likely to occur in patients over 60 years of age, who are usually more sensitive to the effects of cholestyramine.

Pregnancy

	Pregnancy Category	Explanation
All Trimesters	C	Animal studies have shown an adverse effect and there are no adequate studies in pregnant women OR no animal studies have been conducted and there are no adequate studies in pregnant women.

Breast Feeding

Studies suggest that this medication may alter milk production or composition. If an alternative to this medication is not prescribed, you should monitor the infant for side effects and adequate milk intake.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

• Mycophenolate Mofetil


• Mycophenolic Acid

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

• Amiodarone


• Anisindione


• Cephalexin


• Cerivastatin


• Deferasirox


• Diclofenac


• Dicumarol


• Digitoxin


• Digoxin


• Ezetimibe


• Furosemide


• Hydrochlorothiazide


• Leflunomide


• Levothyroxine


• Meloxicam


• Metronidazole


• Phenprocoumon


• Valproic Acid


• Warfarin

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other Medical Problems

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

• Bleeding problems or


• Constipation or


• Gallstones or


• Heart or blood vessel disease or


• Hemorrhoids or


• Stomach ulcer or other stomach problems or


• Underactive thyroid—Cholestyramine may make these conditions worse

• Kidney disease—There is an increased risk of developing electrolyte problems (problems in the blood)

• Phenylketonuria—Phenylalanine in aspartame is included in the sugar-free brand of cholestyramine and should be avoided. Aspartame can cause problems in people with phenylketonuria. Therefore, it is best if you avoid using the sugar-free product.

Proper Use of cholestyramine

This section provides information on the proper use of a number of products that contain cholestyramine. It may not be specific to Novo-Cholamine. Please read with care.

Take this medicine exactly as directed by your doctor. Try not to miss any doses and do not take more medicine than your doctor ordered.

This medicine should never be taken in its dry form, since it could cause you to choke. Instead, always mix as follows:

• Place the medicine in 2 ounces of any beverage and mix thoroughly. Then add an additional 2 to 4 ounces of beverage and again mix thoroughly (it will not dissolve) before drinking. After drinking all the liquid containing the medicine, rinse the glass with a little more liquid and drink that also, to make sure you get all the medicine.


• You may also mix this medicine with milk in hot or regular breakfast cereals, or in thin soups such as tomato or chicken noodle soup. Or you may add it to some pulpy fruits such as crushed pineapple, pears, peaches, or fruit cocktail.

For patients taking this medicine for high cholesterol :

• Importance of diet—Before prescribing medicine for your condition, your doctor will probably try to control your condition by prescribing a personal diet for you. Such a diet may be low in fats, sugars, and/or cholesterol. Many people are able to control their condition by carefully following their doctor's orders for proper diet and exercise. Medicine is prescribed only when additional help is needed. Follow carefully the special diet your doctor gave you, since the medicine is effective only when a schedule of diet and exercise is properly followed.


• Also, this medicine is less effective if you are greatly overweight. It may be very important for you to go on a reducing diet. However, check with your doctor before going on any diet.


• Remember that this medicine will not cure your cholesterol problem but it will help control it. Therefore, you must continue to take it as directed if you expect to lower your cholesterol level.

Dosing

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

• For oral dosage form (powder for oral suspension):
  
  • For high cholesterol or pruritus (itching) related to biliary obstruction:
    
    • Adults—At first, 4 grams one or two times a day before meals. Then, your doctor may increase your dose to 8 to 24 grams a day. This is divided into two to six doses.
    
    
    • Children—At first, 4 grams a day. This is divided into two doses and taken before meals. Then, your doctor may increase your dose to 8 to 24 grams a day. This is divided into two or more doses.
    
    
  
  

Missed Dose

If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Precautions While Using Novo-Cholamine

It is very important that your doctor check your progress at regular visits. This will allow your doctor to see if the medicine is working properly and to decide if you should continue to take it.

Do not take any other medicine unless prescribed by your doctor since cholestyramine may change the effect of other medicines.

Do not stop taking this medicine without first checking with your doctor. When you stop taking this medicine, your blood cholesterol levels may increase again. Your doctor may want you to follow a special diet to help prevent this from happening.

Novo-Cholamine Side Effects

In some animal studies, cholestyramine was found to cause tumors. It is not known whether cholestyramine causes tumors in humans.

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

Rare

• Black, tarry stools


• stomach pain (severe) with nausea and vomiting

Check with your doctor as soon as possible if any of the following side effects occur:

More common

• Constipation

Rare

• Loss of weight (sudden)

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

• Heartburn or indigestion


• nausea or vomiting


• stomach pain

Less common

• Belching


• bloating


• diarrhea


• dizziness


• headache

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

See also: Novo-Cholamine side effects (in more detail)

The information contained in the Thomson Reuters Micromedex products as delivered by Drugs.com is intended as an educational aid only. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs (including any herbal medicines or supplements) or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you.

The use of the Thomson Reuters Healthcare products is at your sole risk. These products are provided "AS IS" and "as available" for use, without warranties of any kind, either express or implied. Thomson Reuters Healthcare and Drugs.com make no representation or warranty as to the accuracy, reliability, timeliness, usefulness or completeness of any of the information contained in the products. Additionally, THOMSON REUTERS HEALTHCARE MAKES NO REPRESENTATION OR WARRANTIES AS TO THE OPINIONS OR OTHER SERVICE OR DATA YOU MAY ACCESS, DOWNLOAD OR USE AS A RESULT OF USE OF THE THOMSON REUTERS HEALTHCARE PRODUCTS. ALL IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE OR USE ARE HEREBY EXCLUDED. Thomson Reuters Healthcare does not assume any responsibility or risk for your use of the Thomson Reuters Healthcare products.

More Novo-Cholamine resources

• Novo-Cholamine Side Effects (in more detail)
• Novo-Cholamine Use in Pregnancy & Breastfeeding
• Novo-Cholamine Drug Interactions
• Novo-Cholamine Support Group
• 11 Reviews for Novo-Cholamine - Add your own review/rating

Compare Novo-Cholamine with other medications

• Crohn's Disease
• Hyperlipoproteinemia
• Hyperlipoproteinemia Type IIa, Elevated LDL
• Hyperlipoproteinemia Type IIb, Elevated LDL VLDL
• Irritable Bowel Syndrome
• Pruritus of Partial Biliary Obstruction

K-Lyte/Cl 25

Pronunciation: bye-KAR-bo-nate/po-TAS-ee-um KLOR-ide
Generic Name: Potassium Bicarbonate/Potassium Chloride
Brand Name: K-Lyte/Cl 25

K-Lyte/Cl 25 is used for:

Preventing or treating low blood potassium levels when the amount of potassium in the diet is inadequate. It may also be used to treat low potassium levels caused by some diseases, severe or prolonged episodes of vomiting or diarrhea, or by certain medicines, such as diuretics.

K-Lyte/Cl 25 is a mineral. It works by replacing excessive potassium lost from the body because of disease or medicines.

Do NOT use K-Lyte/Cl 25 if:

• you are allergic to any ingredient in K-Lyte/Cl 25


• you have adrenal gland failure (Addison disease), elevated blood acid, elevated blood potassium, extensive tissue injury (eg, severe burns), kidney failure, or severe dehydration


• you are taking an aldosterone blocker (eg, eplerenone) or a potassium-sparing diuretic (eg, spironolactone, triamterene)

Contact your doctor or health care provider right away if any of these apply to you.

Before using K-Lyte/Cl 25:

Some medical conditions may interact with K-Lyte/Cl 25. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, planning to become pregnant, or are breast-feeding


• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement


• if you have allergies to medicines, foods, or other substances


• if you have kidney problems

Some MEDICINES MAY INTERACT with K-Lyte/Cl 25. Tell your health care provider if you are taking any other medicines, especially any of the following:

• Aldosterone blockers (eg, eplerenone), angiotensin-converting enzyme (ACE) inhibitors (eg, lisinopril), nonsteroidal anti-inflammatory drugs (NSAIDs) (eg, ibuprofen), or potassium-sparing diuretics (eg, spironolactone, triamterene) because the risk of high blood potassium levels may be increased


• Aluminum salts because the risk of their side effects may be increased by K-Lyte/Cl 25

This may not be a complete list of all interactions that may occur. Ask your health care provider if K-Lyte/Cl 25 may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use K-Lyte/Cl 25:

Use K-Lyte/Cl 25 as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• Take K-Lyte/Cl 25 by mouth with food or after a meal to prevent stomach upset.


• Do not remove the medicine from the package until you are ready to take it. Make sure that your hands are dry when you open the medicine.


• Do not chew or swallow the tablet. Place the tablet in a glass and add at least half a glass (4 oz/120 mL) of cold water, juice, or other beverage. Allow the tablet to dissolve completely and the fizzing to stop, then drink all of the liquid slowly over a 5- to 10-minute period. Rinse the container with an additional small amount of water and drink the contents to ensure the entire dose is taken.


• Do not lie down for 30 minutes after taking K-Lyte/Cl 25.


• If you miss a dose of K-Lyte/Cl 25, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use K-Lyte/Cl 25.

Important safety information:

• Check with your doctor before you use a salt substitute or a product that has potassium in it.


• Lab tests, including blood potassium, kidney function, and electrocardiogram (ECG), may be performed while you use K-Lyte/Cl 25. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.


• Use K-Lyte/Cl 25 with caution in the ELDERLY; they may be more sensitive to its effects.


• K-Lyte/Cl 25 should not be used in CHILDREN; safety and effectiveness in children have not been confirmed.


• PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using K-Lyte/Cl 25 while you are pregnant. K-Lyte/Cl 25 is found in breast milk. Do not breast-feed while taking K-Lyte/Cl 25.

Possible side effects of K-Lyte/Cl 25:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Diarrhea; nausea; stomach discomfort; vomiting.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); black, tarry stools; chest pain; irregular heartbeat; numbness or tingling in your lips, hands, or feet; stomach pain; unusual confusion or anxiety; unusual muscle weakness; vomit that looks like coffee grounds; weak or heavy legs.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

See also: K-Lyte/Cl 25 side effects (in more detail)

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include chest pain; fast, slow, or irregular heartbeat; limp muscles; listlessness; muscle weakness or paralysis; slow or difficult breathing.

Proper storage of K-Lyte/Cl 25:

Store K-Lyte/Cl 25 at room temperature, between 59 and 86 degrees F (15 and 30 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep K-Lyte/Cl 25 out of the reach of children and away from pets.

General information:

• If you have any questions about K-Lyte/Cl 25, please talk with your doctor, pharmacist, or other health care provider.


• K-Lyte/Cl 25 is to be used only by the patient for whom it is prescribed. Do not share it with other people.


• If your symptoms do not improve or if they become worse, check with your doctor.


• Check with your pharmacist about how to dispose of unused medicine.

This information is a summary only. It does not contain all information about K-Lyte/Cl 25. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: February 1, 2012

Database Edition 12.1.1.002

Copyright © 2012 Wolters Kluwer Health, Inc.

More K-Lyte/Cl 25 resources

• K-Lyte/Cl 25 Side Effects (in more detail)
• K-Lyte/Cl 25 Use in Pregnancy & Breastfeeding
• K-Lyte/Cl 25 Drug Interactions
• K-Lyte/Cl 25 Support Group
• 0 Reviews for K-Lyte/Cl 25 - Add your own review/rating

Compare K-Lyte/Cl 25 with other medications

• Hypokalemia
• Prevention of Hypokalemia

Ticagrelor

tye-KA-grel-or

Oral route(Tablet)

Ticagrelor, can cause significant, sometimes fatal, bleeding. Do not use in patients with active pathological bleeding or history of intracranial hemorrhage. Do not start in patients planned to undergo urgent CABG. When possible, discontinue at least 5 days prior to any surgery. Suspect bleeding in any patient who is hypotensive and has recently undergone coronary angiography, percutaneous coronary intervention, CABG, or other surgical procedures in the setting of ticagrelor. If possible, manage bleeding without discontinuing ticagrelor. Stopping ticagrelor increases the risk of subsequent cardiovascular events. Maintenance doses of aspirin above 100 mg reduce the effectiveness of ticagrelor and should be avoided .

Commonly used brand name(s)

In the U.S.

• Brilinta

Available Dosage Forms:

• Tablet

Pharmacologic Class: ADP-Induced Aggregation Inhibitor

Uses For ticagrelor

Ticagrelor is used alone or together with aspirin to lessen the chance of heart attack, stroke, or other serious problems with your heart or blood vessels. It is given to patients who have already had a heart attack or severe chest pain, stroke, or to people with other blood circulation problems that could lead to a stroke or heart attack.

A heart attack or stroke may occur when a blood vessel in the heart or brain is blocked by a blood clot. Ticagrelor reduces the chance that a harmful blood clot will form by preventing certain cells in the blood from clumping together. This effect of ticagrelor may also increase the chance of serious bleeding in some people.

ticagrelor is available only with your doctor's prescription.

Before Using ticagrelor

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For ticagrelor, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to ticagrelor or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies have not been performed on the relationship of age to the effects of ticagrelor in the pediatric population. Safety and efficacy have not been established.

Geriatric

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of ticagrelor in the elderly.

Pregnancy

	Pregnancy Category	Explanation
All Trimesters	C	Animal studies have shown an adverse effect and there are no adequate studies in pregnant women OR no animal studies have been conducted and there are no adequate studies in pregnant women.

Breast Feeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking ticagrelor, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using ticagrelor with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

• Atazanavir


• Carbamazepine


• Clarithromycin


• Dexamethasone


• Indinavir


• Itraconazole


• Ketoconazole


• Nefazodone


• Nelfinavir


• Phenobarbital


• Phenytoin


• Rifampin


• Rifapentine


• Ritonavir


• Rivaroxaban


• Saquinavir


• Telithromycin


• Voriconazole

Using ticagrelor with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

• Digoxin


• Simvastatin

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other Medical Problems

The presence of other medical problems may affect the use of ticagrelor. Make sure you tell your doctor if you have any other medical problems, especially:

• Bleeding, pathological and active (e.g., from peptic ulcers or head injury) or


• Intracranial hemorrhage (bleeding in the head), history of or


• Liver disease, severe—Should not be used in patients with these conditions.

• Bleeding problems, history of or


• Lung disease or breathing problems (e.g., asthma or COPD)—Use with caution. May make these conditions worse.

• Liver disease, moderate—Use with caution. You doctor may adjust your dose.

Proper Use of ticagrelor

Take ticagrelor exactly as directed by your doctor. Ticagrelor will not work properly if you take less of it than directed. Taking more ticagrelor than directed may increase the chance of serious side effects without increasing the helpful effects.

ticagrelor comes with a Medication Guide. It is very important that you read and understand this information. Be sure to ask your doctor about anything you do not understand.

You may take ticagrelor with or without food.

If you are using ticagrelor for a condition called acute coronary syndrome, your doctor may tell you to take aspirin while you are using ticagrelor. In this case, do not change the dose or stop taking the aspirin without talking to your doctor first.

Dosing

The dose of ticagrelor will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of ticagrelor. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

• For oral dosage form (tablets):
  
  • For prevention of blood clots after unstable angina (chest pain), non-ST-elevation myocardial infarction (a type of heart attack), or ST-elevation myocardial infarction or STEMI:
    
    • Adults—At first, 180 milligrams (mg) or 2 tablets taken as a single dose. Then, 90 mg two times a day. Your doctor may also give you a loading dose of aspirin 325 mg once a day, then 75 to 100 mg once a day to be taken together with ticagrelor.
    
    
    • Children—Use and dose must be determined by your doctor.
    
    
  
  

Missed Dose

If you miss a dose of ticagrelor, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Precautions While Using ticagrelor

It is very important that your doctor check your progress at regular visits. This will allow your doctor to see if the medicine is working properly and to decide if you should continue to take it. Blood tests may be needed to check for unwanted effects.

Tell all medical doctors, dentists, nurses, and pharmacists you go to that you are taking ticagrelor. Ticagrelor may increase the risk of serious bleeding during a surgery, other medical procedures (e.g., coronary stent procedure), or some kinds of dental work. You may need to stop using ticagrelor at least 5 days before a surgery, medical procedure, or dental work. Do not stop taking your medicine without your doctor's permission.

While you are using ticagrelor, if you have any kind of bleeding, it may take longer than usual to stop, especially if you hurt yourself. Stay away from rough sports or other situations where you could be bruised, cut, or injured. Be careful when using sharp objects, including razors and fingernail clippers.

ticagrelor may increase your chance of bleeding or bruising. Check with your doctor right away if you notice any unusual bleeding or bruising; black, tarry stools; blood in the urine or stools; or pinpoint red spots on your skin. Avoid picking your nose. If you need to blow your nose, blow it gently.

If you have unexpected or unexplained shortness of breath, difficult or labored breathing, tightness in the chest, or wheezing, tell your doctor right away.

Do not change your dose or stop taking ticagrelor without checking first with your doctor. To do so may increase the chance of having a heart attack, blood clotting problems, or other serious conditions.

Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.

ticagrelor Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

More common

• Difficult or labored breathing


• shortness of breath


• tightness in the chest


• wheezing

Less common

• Blurred vision


• chest pain or discomfort


• confusion


• dizziness


• dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position


• fainting


• fast or irregular heartbeat


• headache


• lightheadedness, dizziness, or fainting


• loss of consciousness


• nervousness


• pounding in the ears


• slow or fast heartbeat


• sweating


• unusual tiredness or weakness

Incidence not known

• Bleeding gums


• bruising


• coughing up blood


• difficulty with breathing or swallowing


• headache, sudden and severe


• increased menstrual flow or vaginal bleeding


• nausea or vomiting


• nosebleeds


• paralysis


• prolonged bleeding from cuts


• red or black, tarry stools


• red or dark brown urine


• weakness

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common

• Back pain


• cough


• diarrhea

Rare

• Swelling of the breasts or breast soreness in both females and males

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

The information contained in the Thomson Reuters Micromedex products as delivered by Drugs.com is intended as an educational aid only. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs (including any herbal medicines or supplements) or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you.

The use of the Thomson Reuters Healthcare products is at your sole risk. These products are provided "AS IS" and "as available" for use, without warranties of any kind, either express or implied. Thomson Reuters Healthcare and Drugs.com make no representation or warranty as to the accuracy, reliability, timeliness, usefulness or completeness of any of the information contained in the products. Additionally, THOMSON REUTERS HEALTHCARE MAKES NO REPRESENTATION OR WARRANTIES AS TO THE OPINIONS OR OTHER SERVICE OR DATA YOU MAY ACCESS, DOWNLOAD OR USE AS A RESULT OF USE OF THE THOMSON REUTERS HEALTHCARE PRODUCTS. ALL IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE OR USE ARE HEREBY EXCLUDED. Thomson Reuters Healthcare does not assume any responsibility or risk for your use of the Thomson Reuters Healthcare products.

Tapentadol

Generic Name: tapentadol (ta PEN ta dol)

Brand Names: Nucynta, Nucynta ER

What is tapentadol?

Tapentadol is in a group of drugs called narcotic pain relievers. It is similar to morphine.

Tapentadol is used to treat moderate to severe chronic pain.

Tapentadol may also be used for purposes not listed in this medication guide.

What is the most important information I should know about tapentadol?

You should not use this medication if you are allergic to tapentadol, or if you have severe liver or kidney disease, if you are having an asthma attack, or if you have a bowel obstruction called paralytic ileus. Do not use tapentadol if you have used an MAO inhibitor such as furazolidone (Furoxone), isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam, Zelapar), or tranylcypromine (Parnate) in the last 14 days. A dangerous drug interaction could occur, leading to serious side effects. Tapentadol may be habit-forming and should be used only by the person it was prescribed for. Keep the medication in a secure place where others cannot get to it. Do not drink alcohol while you are taking tapentadol. Dangerous side effects or death can occur when alcohol is combined with a narcotic pain medicine. Check your food and medicine labels to be sure these products do not contain alcohol.

Never take tapentadol in larger amounts, or for longer than recommended by your doctor. Tell your doctor if the medicine seems to stop working as well in relieving your pain.

This medication may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert. Do not stop using tapentadol suddenly, or you could have unpleasant withdrawal symptoms. Ask your doctor how to avoid withdrawal symptoms when you stop using tapentadol.

What should I discuss with my healthcare provider before taking tapentadol?

You should not use this medication if you are allergic to tapentadol, or if you have severe liver or kidney disease, if you are having an asthma attack, or if you have a bowel obstruction called paralytic ileus. Do not use tapentadol if you have used an MAO inhibitor such as furazolidone (Furoxone), isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam, Zelapar), or tranylcypromine (Parnate) in the last 14 days. A dangerous drug interaction could occur, leading to serious side effects.

To make sure you can safely take tapentadol, tell your doctor if you have any of these other conditions:

• 
  

  asthma, COPD, sleep apnea, or other breathing disorders;

  
  


• liver or kidney disease;


• 
  

  curvature of the spine;

  
  


• 
  

  a history of head injury or brain tumor;

  
  


• 
  

  epilepsy or other seizure disorder;

  
  


• 
  

  gallbladder disease or pancreas problems;

  
  


• 
  

  mental illness; or

  
  


• 
  

  a history of drug or alcohol addiction.

  
  

FDA pregnancy category C. It is not known whether this medication is harmful to an unborn baby. Tapentadol may cause breathing problems and addiction or withdrawal symptoms in a newborn if the mother takes the medication during pregnancy. Tell your doctor if you are pregnant or plan to become pregnant during treatment. Tapentadol can pass into breast milk and may harm a nursing baby. Do not breast-feed while taking this medication.

Older adults may be more sensitive to the effects of this medicine.

Tapentadol may be habit forming and should be used only by the person it was prescribed for. Never share tapentadol with another person, especially someone with a history of drug abuse or addiction. Keep the medication in a place where others cannot get to it. Do not give tapentadol to a child.

How should I take tapentadol?

Take exactly as prescribed. Never take tapentadol in larger amounts, or for longer than recommended by your doctor. Follow the directions on your prescription label. Tell your doctor if the medicine seems to stop working as well in relieving your pain.

Your doctor may occasionally change the timing of your dose to make sure you get the best results.

Take this medicine with a full glass of water.

You may take tapentadol with or without food.

Do not crush, chew, or break an extended-release tablet. Swallow it whole. Breaking or opening the pill may cause too much of the drug to be released at one time.

Tapentadol can cause constipation. Talk to your doctor before using a laxative or stool softener to treat or prevent this side effect.

Do not stop using tapentadol suddenly, or you could have unpleasant withdrawal symptoms. Ask your doctor how to avoid withdrawal symptoms when you stop using tapentadol. Store at room temperature away from moisture and heat.

Keep track of the amount of medicine used from each new bottle. Tapentadol is a drug of abuse and you should be aware if anyone is using your medicine improperly or without a prescription.

Ask a pharmacist about how to dispose of any unused pills after you have stopped taking tapentadol.

Never crush a tablet or other pill to mix into a liquid for snorting tapentadol or injecting the drug into your vein. This practice has resulted in death with the misuse of narcotic pain medicines and similar prescription drugs.

See also: Tapentadol dosage (in more detail)

What happens if I miss a dose?

Since tapentadol is taken as needed, you may not be on a dosing schedule. If you are taking the medication regularly, take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose of tapentadol can be fatal.

Overdose symptoms may include extreme drowsiness, blurred vision, confusion, vomiting, cold and clammy skin, weak pulse, shallow breathing, fainting, or breathing that stops.

What should I avoid while taking tapentadol?

This medication may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert. Do not drink alcohol while you are using tapentadol. Dangerous side effects or death can occur when alcohol is combined with tapentadol. Check your food and medicine labels to be sure these products do not contain alcohol.

Tapentadol side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat. Call your doctor at once if you have a serious side effect such as:

• 
  

  weak or shallow breathing, weak pulse, slow heartbeat;

  
  


• 
  

  seizure (convulsions);

  
  


• 
  

  severe drowsiness or dizziness;

  
  


• 
  

  confusion, problems with speech or balance; or

  
  


• 
  

  agitation, hallucinations, fever, fast heart rate, overactive reflexes, nausea, vomiting, diarrhea, loss of coordination, fainting.

  
  

Less serious side effects may include:

• 
  

  mild nausea or vomiting;

  
  


• 
  

  constipation;

  
  


• 
  

  mild dizziness, drowsiness;

  
  


• 
  

  dry mouth;

  
  


• 
  

  itching; or

  
  


• 
  

  increased sweating.

  
  

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Tapentadol Dosing Information

Usual Adult Dose for Pain:

Immediate release:
50 mg, 75 mg, or 100 mg orally every 4 to 6 hours depending upon pain intensity, with or without food.
On the first day of dosing, the second dose may be administered as soon as one hour after the first dose, if adequate pain relief is not attained with the first dose. Subsequent dosing is 50 mg, 75 mg, or 100 mg every 4 to 6 hours and should be adjusted to maintain adequate analgesia with acceptable tolerability. Daily doses greater than 700 mg on the first day of therapy and 600 mg on subsequent days have not been studied and are, therefore, not recommended.

Extended release:
Opioid naive: Initial: 50 mg twice daily (recommended interval: 12 hours); titrate in increments of 50 mg no more frequently than twice daily every 3 days to effective dose (therapeutic range: 100 to 250 mg twice daily) (maximum dose: 500 mg/day)

Opioid experienced: Initial: 50 mg titrated to an effective dose; titrate in increments of 50 mg no more frequently than twice daily every 3 days (therapeutic range: 100 to 250 mg twice daily) (maximum dose: 500 mg/day). Note: No adequate data on converting patients from other opioids to tapentadol extended release.

Conversion from immediate release to extended release: Convert using same total daily dose but divide into two equal doses and administer twice daily (recommended interval: 12 hours) (maximum dose: 500 mg/day).

What other drugs will affect tapentadol?

Cold or allergy medicine, sedatives, narcotic pain medicine, sleeping pills, muscle relaxers, and medicine for seizures, depression or anxiety can add to sleepiness caused by tapentadol. Tell your doctor if you regularly use any of these medicines, or any other narcotic pain medicines.

There may be other drugs that can interact with tapentadol. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.

More tapentadol resources

• Tapentadol Side Effects (in more detail)
• Tapentadol Dosage
• Tapentadol Use in Pregnancy & Breastfeeding
• Tapentadol Drug Interactions
• Tapentadol Support Group
• 105 Reviews for Tapentadol - Add your own review/rating

• tapentadol Advanced Consumer (Micromedex) - Includes Dosage Information


• Tapentadol Professional Patient Advice (Wolters Kluwer)


• Tapentadol MedFacts Consumer Leaflet (Wolters Kluwer)


• Nucynta Prescribing Information (FDA)


• Nucynta Monograph (AHFS DI)


• Nucynta Consumer Overview


• Nucynta ER Prescribing Information (FDA)


• Nucynta ER Extended-Release Tablets MedFacts Consumer Leaflet (Wolters Kluwer)

Compare tapentadol with other medications

• Diabetic Nerve Damage
• Pain

Where can I get more information?

• Your pharmacist can provide more information about tapentadol.

See also: tapentadol side effects (in more detail)

Treanda

Generic Name: bendamustine (BEN da MUS teen)

Brand Names: Treanda

What is bendamustine?

Bendamustine is a cancer medication that interferes with the growth of cancer cells and slows their growth and spread in the body.

Bendamustine is used to treat chronic lymphocytic leukemia. Bendamustine is also used to treat indolent B-cell non-Hodgkin lymphoma after other medications have been tried without successful treatment of this condition.

Bendamustine may also be used for purposes not listed in this medication guide.

What is the most important information I should know about bendamustine?

You should not receive this medication if you are allergic to bendamustine or mannitol (Osmitrol). Do not receive bendamustine if you are pregnant. It could harm the unborn baby.

Before you receive bendamustine, tell your doctor if you have a weak immune system, fever or other signs of infection, a metabolic disorder or electrolyte imbalance, liver or kidney disease, or if you smoke.

Tell your caregiver right away if you have a fever, chills, itching, or skin rash during or shortly after the injection.

Other serious side effects to tell your doctor about include fever, chills, cough, sore throat, feeling short of breath, pale skin, easy bruising or bleeding, unusual weakness, severe skin rash, weak pulse, muscle weakness, fast or slow heart rate, confusion, lower back pain, blood in your urine, urinating less than usual, or swelling, redness, or signs of where the medicine was injected.

To be sure this medication is not causing harmful effects, your blood may need to be tested often. Your kidney or liver function may also need to be tested. Visit your doctor regularly.

What should I discuss with my healthcare provider before I receive bendamustine?

You should not receive this medication if you are allergic to bendamustine or mannitol (Osmitrol).

To make sure you can safely receive bendamustine, tell your doctor if you have any of these other conditions:

• 
  

  a weak immune system;

  
  


• 
  

  fever or other signs of infection;

  
  


• 
  

  a metabolic disorder or electrolyte imbalance;

  
  


• liver disease;


• kidney disease; or


• 
  

  if you smoke.

  
  

FDA pregnancy category D. Do not receive bendamustine if you are pregnant. It could harm the unborn baby. Use effective birth control, and tell your doctor if you become pregnant during treatment. It is not known whether bendamustine passes into breast milk or if it could harm a nursing baby. Do not receive this medication without telling your doctor if you are breast-feeding a baby.

Some people receiving bendamustine have developed certain types of cancers. It is not known whether this medication causes cancer. Talk with your doctor about the risks and benefits of using bendamustine.

How is bendamustine given?

Bendamustine is injected into a vein through an IV. You will receive this injection in a clinic or hospital setting. Bendamustine must be given slowly, and the IV infusion can take at least 30 minutes to complete.

Bendamustine is usually given for 2 days in a row every 21 to 28 days. You may receive up to 8 treatments total, depending on the condition being treated. Follow your doctor's instructions.

You may be given other medications to help prevent certain side effects of bendamustine.

Tell your caregivers if you feel any burning, pain, or swelling around the IV needle when the medicine is injected.

To be sure this medication is not causing harmful effects, your blood may need to be tested often. Your kidney or liver function may also need to be tested. Visit your doctor regularly.

What happens if I miss a dose?

Call your doctor for instructions if you miss an appointment for your bendamustine injection.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose symptoms may include drowsiness, tremors, slow or shallow breathing, loss of balance or coordination, or seizure (convulsions).

What should I avoid while receiving bendamustine?

Bendamustine may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert.

Bendamustine side effects

Some people receiving a bendamustine injection have had a reaction to the infusion (when the medicine is injected into the vein). Tell your caregiver right away if you have fever, chills, itching, or skin rash during or shortly after the injection. Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Tell your caregivers at once if you have a serious side effect such as:

• 
  

  fever, chills, body aches, flu symptoms, sores in your mouth and throat;

  
  


• 
  

  pale skin, feeling light-headed or short of breath, rapid heart rate, trouble concentrating;

  
  


• 
  

  easy bruising or bleeding, purple or red pinpoint spots under your skin, unusual weakness;

  
  


• 
  

  cold symptoms such as stuffy nose, sneezing, cough, sore throat;

  
  


• 
  

  lower back pain, blood in your urine, urinating less than usual or not at all;

  
  


• 
  

  numbness or tingly feeling around your mouth;

  
  


• 
  

  muscle weakness, tightness, or contraction, overactive reflexes;

  
  


• 
  

  fast or slow heart rate, weak pulse, confusion;

  
  


• 
  

  dry mouth, feeling very thirsty or hot, heavy sweating or hot and dry skin;

  
  


• 
  

  severe blistering, peeling, and red skin rash; or

  
  


• 
  

  pain, swelling, redness, skin changes, or signs of infection where the medicine was injected.

  
  

Less serious side effects may include:

• 
  

  mild nausea, vomiting, diarrhea, constipation, or upset stomach;

  
  


• 
  

  swelling in your hands or feet;

  
  


• 
  

  headache, dizziness, drowsiness;

  
  


• 
  

  loss of appetite, weight loss; or

  
  


• 
  

  mild skin rash.

  
  

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect bendamustine?

Tell your doctor about all other medications you use, especially:

• 
  

  allopurinol (Zyloprim);

  
  


• 
  

  carbamazepine (Carbatrol, Equetro, Tegretol);

  
  


• 
  

  cimetidine (Tagamet);

  
  


• 
  

  ciprofloxacin (Cipro);

  
  


• 
  

  fluvoxamine (Luvox);

  
  


• 
  

  omeprazole (Prilosec);

  
  


• 
  

  thiabendazole (Mintezol); or

  
  


• 
  

  a barbiturate such as butabarbital (Butisol), secobarbital (Seconal), phenobarbital (Solfoton), and others.

  
  

This list is not complete and other drugs may interact with bendamustine. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.

More Treanda resources

• Treanda Side Effects (in more detail)
• Treanda Use in Pregnancy & Breastfeeding
• Treanda Drug Interactions
• Treanda Support Group
• 1 Review for Treanda - Add your own review/rating

• Treanda Prescribing Information (FDA)


• Treanda Advanced Consumer (Micromedex) - Includes Dosage Information


• Treanda MedFacts Consumer Leaflet (Wolters Kluwer)


• Treanda Consumer Overview

Compare Treanda with other medications

• Chronic Lymphocytic Leukemia
• Non-Hodgkin's Lymphoma

Where can I get more information?

• Your doctor or pharmacist can provide more information about bendamustine.

See also: Treanda side effects (in more detail)

Somatropin (rDNA origin - Refrigerated) Cartridge

Pronunciation: SOE-ma-TROE-pin
Generic Name: Somatropin (rDNA origin - Refrigerated)
Brand Name: Humatrope

Somatropin (rDNA origin - Refrigerated) Cartridge is used for:

Treating certain children or adults when the body does not produce enough growth hormone. It is also used to treat certain children who are not growing normally because of Turner syndrome or certain other conditions (eg, idiopathic short stature, short stature homeobox-containing gene [SHOX] deficiency). It may also be used for other conditions as determined by your doctor.

Somatropin (rDNA origin - Refrigerated) Cartridge is a growth hormone. It works by stimulating growth in patients who do not make enough natural growth hormone.

Do NOT use Somatropin (rDNA origin - Refrigerated) Cartridge if:

• you are allergic to any ingredient in Somatropin (rDNA origin - Refrigerated) Cartridge or in the diluent, including metacresol or glycerin


• you have active or recurring cancer or brain tumor, or you currently receive treatment for cancer


• you have severe breathing problems (eg, respiratory failure) or a serious illness caused by complications from a surgery or injury


• you have a certain type of eye problem caused by diabetes (diabetic retinopathy)


• the patient is a child who has Prader-Willi syndrome and is severely overweight or has severe breathing problems (eg, respiratory infection, history of airway blockage or sleep apnea)


• the patient is a child who has epiphyseal closure (bone growth is complete)

Contact your doctor or health care provider right away if any of these apply to you.

Before using Somatropin (rDNA origin - Refrigerated) Cartridge:

Some medical conditions may interact with Somatropin (rDNA origin - Refrigerated) Cartridge. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, planning to become pregnant, or are breast-feeding


• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement


• if you have allergies to medicines, foods, or other substances


• if you have a history of kidney or liver problems, lung or breathing problems (eg, airway blockage, respiratory infection, sleep apnea), an underactive thyroid, heart problems, high blood pressure, ear or hearing problems (eg, repeated ear infections), pancreas problems, or endocrine problems (eg, pituitary or adrenal gland problems)


• if you have a history of diabetes or high blood sugar levels, or if a member of your family has had diabetes


• if you have a history of leukemia, other types of cancer (eg, skin cancer), or any unusual growths or tumors (especially in the brain)


• if you have curvature of the spine (scoliosis), Prader-Willi syndrome, or a certain eye problem called papilledema (swelling of the area around your optic nerve)


• if you are very overweight or have had a recent major surgery or injury

Some MEDICINES MAY INTERACT with Somatropin (rDNA origin - Refrigerated) Cartridge. Tell your health care provider if you are taking any other medicines, especially any of the following:

• Corticosteroids (eg, prednisone) or estrogens because they may decrease Somatropin (rDNA origin - Refrigerated) Cartridge's effectiveness


• Anticonvulsants (eg, carbamazepine) or cyclosporine because the risk of their side effects may be increased by Somatropin (rDNA origin - Refrigerated) Cartridge


• Insulin or other medicines for diabetes because their effectiveness may be decreased by Somatropin (rDNA origin - Refrigerated) Cartridge

This may not be a complete list of all interactions that may occur. Ask your health care provider if Somatropin (rDNA origin - Refrigerated) Cartridge may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Somatropin (rDNA origin - Refrigerated) Cartridge:

Use Somatropin (rDNA origin - Refrigerated) Cartridge as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• An extra patient leaflet is available with Somatropin (rDNA origin - Refrigerated) Cartridge. Talk to your pharmacist if you have questions about this information.


• Somatropin (rDNA origin - Refrigerated) Cartridge is given as an injection under the skin. A health care provider will teach you how to use it. Be sure you understand how to use Somatropin (rDNA origin - Refrigerated) Cartridge. Follow the procedures you are taught when you use a dose. Contact your health care provider if you have any questions.


• Somatropin (rDNA origin - Refrigerated) Cartridge should only be used with a certain kind of pen device. Ask your health care provider if you have any questions.


• Do NOT shake Somatropin (rDNA origin - Refrigerated) Cartridge. Swirl gently to mix.


• Somatropin (rDNA origin - Refrigerated) Cartridge should be clear and colorless. Do not use Somatropin (rDNA origin - Refrigerated) Cartridge if it contains particles, is cloudy or discolored, or if the container is cracked or damaged.


• Be sure to rotate your injection site as directed to help avoid thickening or hardening of the skin.


• Keep this product, as well as syringes and needles, out of the reach of children and pets. Do not reuse needles, syringes, or other materials. Ask your health care provider how to dispose of these materials after use. Follow all local rules for disposal.


• If you miss a dose of Somatropin (rDNA origin - Refrigerated) Cartridge, use it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not use 2 doses at once.

Ask your health care provider any questions you may have about how to use Somatropin (rDNA origin - Refrigerated) Cartridge.

Important safety information:

• Severe and sometimes fatal lung and breathing problems have occurred with the use of Somatropin (rDNA origin - Refrigerated) Cartridge in certain children with Prader-Willi syndrome. These children were usually either very overweight or had severe breathing problems (eg, airway blockage, sleep apnea, lung or airway infection). The risk may be greater in boys. Children with Prader-Willi syndrome should have certain breathing tests before they start Somatropin (rDNA origin - Refrigerated) Cartridge. They should be monitored for signs of lung or airway infection. They should also have effective weight control. Contact the doctor at once if the patient develops irregular breathing during sleep, new or increased snoring, or symptoms of lung or airway infection (eg, fever, coughing, sore throat, shortness of breath, chest pain or discomfort).


• Rarely, children using Somatropin (rDNA origin - Refrigerated) Cartridge have experienced a slipped growth plate in the hip. Contact the doctor right away if the patient develops hip or knee pain or a limp.


• Rarely, increased blood pressure in the head has been reported in patients using somatropin. The risk may be greater in patients with Turner syndrome or Prader-Willi syndrome. Symptoms usually occurred within the first 8 weeks after the start of treatment. The symptoms have gone away after the dose was lowered or treatment was stopped. Discuss any questions or concerns with your doctor. Contact your doctor right away if you develop symptoms such as vision changes or severe headache, nausea, or vomiting.


• Pancreas inflammation (pancreatitis) has been reported rarely in patients who take Somatropin (rDNA origin - Refrigerated) Cartridge. The risk may be greater in children, especially in girls who have Turner syndrome. Contact your doctor right away if you develop stomach or back pain.


• Somatropin (rDNA origin - Refrigerated) Cartridge may raise your blood sugar. High blood sugar may make you feel confused, drowsy, or thirsty. It can also make you flush, breathe faster, or have a fruit-like breath odor. If these symptoms occur, tell your doctor right away.


• Diabetes patients - Somatropin (rDNA origin - Refrigerated) Cartridge may affect your blood sugar. Check blood sugar levels closely. Ask your doctor before you change the dose of your diabetes medicine.


• Lab tests, including blood sugar levels, eye exams, and thyroid function, may be performed while you use Somatropin (rDNA origin - Refrigerated) Cartridge. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.


• Use Somatropin (rDNA origin - Refrigerated) Cartridge with caution in the ELDERLY; they may be more sensitive to its effects.


• Caution is advised when using Somatropin (rDNA origin - Refrigerated) Cartridge in CHILDREN; they may be more sensitive to its effects, especially pancreas inflammation.


• PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Somatropin (rDNA origin - Refrigerated) Cartridge while you are pregnant. It is not known if Somatropin (rDNA origin - Refrigerated) Cartridge is found in breast milk. If you are or will be breast-feeding while you use Somatropin (rDNA origin - Refrigerated) Cartridge, check with your doctor. Discuss any possible risks to your baby.

Possible side effects of Somatropin (rDNA origin - Refrigerated) Cartridge:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Back pain; headache; increased cough; mild flu-like symptoms; mild swelling (eg, of the hands or feet); muscle or joint pain; redness or itching at the injection site; sore throat; stuffy or runny nose.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); breast enlargement in males; burning, tingling, or numbness; change in appearance or size of a mole; chest pain or discomfort; confusion; ear pain, discharge, or discomfort; fever; hearing problems; hip or knee pain; limp; nausea or vomiting; new growth on the skin; one-sided weakness; persistent or severe cough or sore throat; severe or persistent muscle or joint pain; severe or persistent stomach or back pain; severe or persistent swelling of the hands, ankles, or feet; shortness of breath; slurred speech; snoring or irregular breathing during sleep; sudden, severe, or persistent headache or dizziness; symptoms of high blood sugar (eg, increased thirst, hunger, or urination; unusual weakness); thickened or hardened skin at the injection site; trouble breathing; unusual bruising; vision changes.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

See also: Somatropin (rDNA origin - Refrigerated) side effects (in more detail)

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include swelling of the hands, ankles, or feet; symptoms of high or low blood sugar (eg, dizziness; fainting; fast breathing; fast heartbeat; flushing; increased sweating; increased thirst, hunger, or urination; vision changes; unusual weakness).

Proper storage of Somatropin (rDNA origin - Refrigerated) Cartridge:

Store new (unopened) cartridges in the refrigerator, between 36 and 46 degrees F (2 and 8 degrees C). Do not freeze. Protect from light. Do not use Somatropin (rDNA origin - Refrigerated) Cartridge past the expiration date on the product label.

After mixing, store cartridges in the refrigerator, between 36 and 46 degrees F (2 and 8 degrees C). Do not freeze. Store without the needle attached. Throw away cartridges after 28 days, even if they still contain medicine.

Contact your pharmacist if you have any questions about how to properly store Somatropin (rDNA origin - Refrigerated) Cartridge. Keep Somatropin (rDNA origin - Refrigerated) Cartridge out of the reach of children and away from pets.

General information:

• If you have any questions about Somatropin (rDNA origin - Refrigerated) Cartridge, please talk with your doctor, pharmacist, or other health care provider.


• Somatropin (rDNA origin - Refrigerated) Cartridge is to be used only by the patient for whom it is prescribed. Do not share it with other people.


• If your symptoms do not improve or if they become worse, check with your doctor.


• Check with your pharmacist about how to dispose of unused medicine.

This information is a summary only. It does not contain all information about Somatropin (rDNA origin - Refrigerated) Cartridge. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: February 1, 2012

Database Edition 12.1.1.002

Copyright © 2012 Wolters Kluwer Health, Inc.

More Somatropin (rDNA origin - Refrigerated) resources

• Somatropin (rDNA origin - Refrigerated) Side Effects (in more detail)
• Somatropin (rDNA origin - Refrigerated) Use in Pregnancy & Breastfeeding
• Somatropin (rDNA origin - Refrigerated) Drug Interactions
• Somatropin (rDNA origin - Refrigerated) Support Group
• 13 Reviews for Somatropin (rDNA origin - Refrigerated) - Add your own review/rating

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K-Dur Controlled-Release Tablets

Pronunciation: po-TAS-ee-um KLOR-ide
Generic Name: Potassium Chloride
Brand Name: Examples include K-Dur and Klor-Con M10

K-Dur Controlled-Release Tablets are used for:

Preventing or treating low blood potassium levels in certain patients. Low blood potassium levels may be caused by certain diseases, severe or prolonged episodes of vomiting or diarrhea, certain medicines (eg, corticosteroids, digitalis, diuretics), surgery, or other conditions. It may also be used for other conditions as determined by your doctor.

K-Dur Controlled-Release Tablets are an electrolyte. It works by providing potassium when you have low levels of potassium in your blood.

Do NOT use K-Dur Controlled-Release Tablets if:

• you are allergic to any ingredient in K-Dur Controlled-Release Tablets


• you have high blood potassium levels, severe kidney problems, narrowing of the esophagus because of an enlarged heart, or a blockage, slowing, or paralysis of the esophagus, stomach, or intestines


• you are taking an aldosterone blocker (eg, eplerenone), an anticholinergic (eg, methscopolamine), or a potassium-sparing diuretic (eg, spironolactone, triamterene)

Contact your doctor or health care provider right away if any of these apply to you.

Before using K-Dur Controlled-Release Tablets:

Some medical conditions may interact with K-Dur Controlled-Release Tablets. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, planning to become pregnant, or are breast-feeding


• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement


• if you have allergies to medicines, foods, or other substances


• if you have adrenal gland, esophagus, kidney, or potassium excretion problems; diabetes; diarrhea; extensive tissue injury (eg, severe burns); heart problems (eg, irregular heartbeat, heart failure, mitral valve replacement); heat cramps; high blood acid levels; high blood pressure; muscle weakness or paralysis; or scleroderma; or if you are dehydrated


• if you are confined to a bed or chair

Some MEDICINES MAY INTERACT with K-Dur Controlled-Release Tablets. Tell your health care provider if you are taking any other medicines, especially any of the following:

• Aldosterone blockers (eg, eplerenone), angiotensin-converting enzyme (ACE) inhibitors (eg, lisinopril), nonsteroidal anti-inflammatory drugs (NSAIDs) (eg, ibuprofen), or potassium-sparing diuretics (eg, spironolactone, triamterene) because the risk of high blood potassium levels may be increased


• Anticholinergics (eg, methscopolamine) because the risk of esophagus, intestinal, or stomach problems may be increased


• Digoxin because the risk of its side effects may be increased by K-Dur Controlled-Release Tablets

This may not be a complete list of all interactions that may occur. Ask your health care provider if K-Dur Controlled-Release Tablets may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use K-Dur Controlled-Release Tablets:

Use K-Dur Controlled-Release Tablets as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• Take K-Dur Controlled-Release Tablets by mouth with food or after a meal.


• Take K-Dur Controlled-Release Tablets with a full glass of water (8 oz/240 mL). Do not lie down for 30 minutes after taking K-Dur Controlled-Release Tablets.


• Swallow K-Dur Controlled-Release Tablets whole. Do not crush, chew, or suck on the tablet before swallowing.


• If you have trouble swallowing the tablet whole, you may break the tablet in half and swallow each half separately with a glass of water. You may also dissolve the tablet in half a glass (4 oz/120 mL) of water. Let the tablet dissolve for 2 minutes, then stir well for half a minute. Swirl and drink all the liquid right away. Add 1 oz/30 mL of water to the glass, swirl, and drink; repeat this 1 more time to ensure you have taken all of the medicine.


• Throw away any unused mixture. Do not store the mixture for future use.


• If you miss a dose of K-Dur Controlled-Release Tablets, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use K-Dur Controlled-Release Tablets.

Important safety information:

• Do NOT take more than the recommended dose or use for longer than prescribed without checking with your doctor.


• Check with your doctor before you use a salt substitute or a product that has potassium in it.


• If you have trouble swallowing K-Dur Controlled-Release Tablets, or if it seems to stick to your throat, check with your doctor.


• Lab tests, including blood potassium, kidney function, and electrocardiograms (ECG), may be performed while you use K-Dur Controlled-Release Tablets. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.


• Use K-Dur Controlled-Release Tablets with caution in the ELDERLY; they may be more sensitive to its effects.


• K-Dur Controlled-Release Tablets should be used with extreme caution in CHILDREN; safety and effectiveness in children have not been confirmed.


• PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using K-Dur Controlled-Release Tablets while you are pregnant. K-Dur Controlled-Release Tablets are found in breast milk. If you are or will be breast-feeding while you use K-Dur Controlled-Release Tablets, check with your doctor. Discuss any possible risks to your baby.

Possible side effects of K-Dur Controlled-Release Tablets:

All medicines may cause side effects, but many people have no, or minor side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Diarrhea; gas; nausea; stomach discomfort; vomiting.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); black, tarry stools; chest pain; irregular heartbeat; listlessness; numbness or tingling in your skin, lips, hands, or feet; severe nausea or vomiting; stomach pain or swelling; unusual confusion or anxiety; unusual muscle weakness or paralysis; vomit that looks like coffee grounds; weak or heavy legs.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

See also: K-Dur side effects (in more detail)

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include chest pain; fast, slow, or irregular heartbeat; limp muscles; listlessness; muscle weakness or paralysis; slow or difficult breathing.

Proper storage of K-Dur Controlled-Release Tablets:

Store K-Dur Controlled-Release Tablets at 77 degrees F (25 degrees C). Brief storage at temperatures between 59 and 86 degrees F (15 and 30 degrees C) is permitted. Store away from heat, moisture, and light. Do not store in the bathroom. Keep K-Dur Controlled-Release Tablets out of the reach of children and away from pets.

General information:

• If you have any questions about K-Dur Controlled-Release Tablets, please talk with your doctor, pharmacist, or other health care provider.


• K-Dur Controlled-Release Tablets are to be used only by the patient for whom it is prescribed. Do not share it with other people.


• If your symptoms do not improve or if they become worse, check with your doctor.


• Check with your pharmacist about how to dispose of unused medicine.

This information is a summary only. It does not contain all information about K-Dur Controlled-Release Tablets. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: February 1, 2012

Database Edition 12.1.1.002

Copyright © 2012 Wolters Kluwer Health, Inc.

More K-Dur resources

• K-Dur Side Effects (in more detail)
• K-Dur Use in Pregnancy & Breastfeeding
• K-Dur Drug Interactions
• K-Dur Support Group
• 0 Reviews for K-Dur - Add your own review/rating

Compare K-Dur with other medications

• Hypokalemia
• Prevention of Hypokalemia